10,559 research outputs found
Trithorax group proteins: switching genes on and keeping them active
Cellular memory is provided by two counteracting groups of chromatin proteins termed Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate transcription and are perhaps best known because of the involvement of the TrxG protein MLL in leukaemia. However, in terms of molecular analysis, they have lived in the shadow of their more famous counterparts, the PcG proteins. Recent advances have improved our understanding of TrxG protein function and demonstrated that the heterogeneous group of TrxG proteins is of critical importance in the epigenetic regulation of the cell cycle, senescence, DNA damage and stem cell biology
Spin-orbit-enhanced Wigner localization in quantum dots
We investigate quantum dots with Rashba spin-orbit coupling in the
strongly-correlated regime. We show that the presence of the Rashba interaction
enhances the Wigner localization in these systems, making it achievable for
higher densities than those at which it is observed in Rashba-free quantum
dots. Recurring shapes in the pair-correlated densities of the yrast spectrum,
which might be associated with rotational and vibrational modes, are also
reported.Comment: 5 pages, 4 figure
The high-pressure behavior of CaMoO4
We report a high-pressure study of tetragonal scheelite-type CaMoO4 up to 29
GPa. In order to characterize its high-pressure behavior, we have combined
Raman and optical-absorption measurements with density-functional theory
calculations. We have found evidence of a pressure-induced phase transition
near 15 GPa. Experiments and calculations agree in assigning the high-pressure
phase to a monoclinic fergusonite-type structure. The reported results are
consistent with previous powder x-ray-diffraction experiments, but are in
contradiction with the conclusions obtained from earlier Raman measurements,
which support the existence of more than one phase transition in the pressure
range covered by our studies. The observed scheelite-fergusonite transition
induces significant changes in the electronic band gap and phonon spectrum of
CaMoO4. We have determined the pressure evolution of the band gap for the low-
and high-pressure phases as well as the frequencies and pressure dependences of
the Raman-active and infrared-active modes. In addition, based upon
calculations of the phonon dispersion of the scheelite phase, carried out at a
pressure higher than the transition pressure, we propose a possible mechanism
for the reported phase transition. Furthermore, from the calculations we
determined the pressure dependence of the unit-cell parameters and atomic
positions of the different phases and their room-temperature equations of
state. These results are compared with previous experiments showing a very good
agreement. Finally, information on bond compressibility is reported and
correlated with the macroscopic compressibility of CaMoO4. The reported results
are of interest for the many technological applications of this oxide.Comment: 36 pages, 10 figures, 8 table
Organic matter in forest arrangements within the Crop-Livestock-Forest Integration System in Mato Grosso State.
In Mato Grosso State, the main objectives of this integration are the shading provided to the animals, the improvement in the pastures? fertility, and the availability of wood for use at the property
Soil P, K, and Al contents in a Crop-Livestock-Forest integration system in Mato Grosso State.
The objective of this study was to evaluate the soil P, K, and Al contents in a CLFi system established in Nova Canaã do Norte-MT, Brazil
Colloidal CuFeS2 Nanocrystals: Intermediate Fe d-Band Leads to High Photothermal Conversion Efficiency
We describe the colloidal hot-injection synthesis of phase-pure nanocrystals
(NCs) of a highly abundant mineral, chalcopyrite (CuFeS2). Absorption bands
centered at around 480 and 950 nm, spanning almost the entire visible and near
infrared regions, encompass their optical extinction characteristics. These
peaks are ascribable to electronic transitions from the valence band (VB) to
the empty intermediate band (IB), located in the fundamental gap and mainly
composed of Fe 3d orbitals. Laser-irradiation (at 808 nm) of an aqueous
suspension of CuFeS2 NCs exhibited significant heating, with a photothermal
conversion efficiency of 49%. Such efficient heating is ascribable to the
carrier relaxation within the broad IB band (owing to the indirect VB-IB gap),
as corroborated by transient absorption measurements. The intense absorption
and high photothermal transduction efficiency (PTE) of these NCs in the
so-called biological window (650-900 nm) makes them suitable for photothermal
therapy as demonstrated by tumor cell annihilation upon laser irradiation. The
otherwise harmless nature of these NCs in dark conditions was confirmed by in
vitro toxicity tests on two different cell lines. The presence of the deep Fe
levels constituting the IB is the origin of such enhanced PTE, which can be
used to design other high performing NC photothermal agents.Comment: 12 pages, Chemistry of Materials, 31-May-201
Voltage-independent SK-channel dysfunction causes neuronal hyperexcitability in the hippocampus of Fmr1 knock-out mice
Neuronal hyperexcitability is one of the major characteristics of fragile X syndrome (FXS), yet the molecular mechanisms of this critical dysfunction remain poorly understood. Here we report a major role of voltage-independent potassium (
Next-to-leading order QCD predictions for the hadronic +jet production
We calculate the next-to-leading order(NLO) QCD corrections to the
production in association with a jet at hadron colliders. We study the impacts
of the complete NLO QCD radiative corrections to the integrated cross sections,
the scale dependence of the cross sections, and the differential cross sections
(, ) of the final -,
Higgs-boson and jet. We find that the corrections significantly modify the
physical observables, and reduce the scale uncertainty of the LO cross section.
Our results show that by applying the inclusive scheme with and taking , , the
K-factor is 1.15 for the process at the Tevatron,
while the K-factors for the processes and
at the LHC are 1.12 and 1.08 respectively. We conclude that to understand the
hadronic associated production, it is necessary to study the NLO QCD
corrections to production process which is part of the inclusive
production.Comment: 26 pages, 27 figures, accepted by Phys. Rev.
Prediction of Local Structural Stabilities of Proteins from Their Amino Acid Sequences
Hydrogen exchange experiments provide detailed information about the local stability and the solvent accessibility of different regions of the structures of folded proteins, protein complexes, and amyloid fibrils. We introduce an approach to predict protection factors from hydrogen exchange in proteins based on the knowledge of their amino acid sequences without the inclusion of any additional structural information. These results suggest that the propensity of different regions of the structures of globular proteins to undergo local unfolding events can be predicted from their amino acid sequences with an accuracy of 80% or better. © 2007 Elsevier Ltd. All rights reserved
Performance analysis of MPEG-4 decoder and encoder
© 2002 Croatian Soc. Electronics in Marine-ELMAR. A performance analysis of MPEG-4 encoder and decoder programs on a standard personal computer is presented. The paper first describes the MPEG-4 computational load and discusses related works, then outlines the performance analysis. Experimental results show that while the decoder program can be easily executed in real time, the encoder requires execution times in the order of seconds per frame which call for substantial optimisation to satisfy real-time constraints
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